Recommendations for machine learning-assisted directed evolution with limited data

This manuscript (permalink) was automatically generated from gitter-lab/low-n-mlde-review@f2c9c47 on August 30, 2024.

Authors

✉ — Correspondence possible via GitHub Issues

Abstract

This manuscript is a community perspective about recommendations for protein engineering in the low N setting [1] where there is little experimental sequence-function data available. It focuses on techniques guided by machine learning.

References

1.
Low-N protein engineering with data-efficient deep learning
Surojit Biswas, Grigory Khimulya, Ethan C Alley, Kevin M Esvelt, George M Church
Nature Methods (2021-04) https://doi.org/gknjq8